Article
[Two doses of the paternal Tme gene do not compensate for the lethality of the Thp deletion in mice].
Genetika - 1 Nov 1990
Agul'nik A I, Agul'nik S I, Rubinskiĭ A O
Abstract excerpt
The hairpin-tail (Thp) deletion in chromosome 17 is lethal when inherited from the mother. Heterozygotes with this deletion, paternal in origin, are viable. The Thp maternal effect is related to a deficiency of Tme gene located in the Thp deleted region. Herein, the viability of mice with tertiary trisomy of chromosome 17Ts(17(16))43H with different doses of the paternal and maternal Tme alleles is analysed. It...
Topics
- Alleles
- Animals
- Chromosome Deletion
- Dosage Compensation, Genetic
- Genes, Lethal
- Heterozygote
- Mice
- Mice, Mutant Strains
- Trisomy