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Article

Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site.

Biochemistry - 1 Apr 1997

Sohl J L, Shiau A K, Rader S D, Wilk B J, Agard D A

Abstract excerpt

alpha-Lytic protease, a chymotrypsin-like serine protease, is synthesized with an N-terminal 166 amino acid pro region which is absolutely required for folding of the protease. The pro region is also the most potent inhibitor of the protease known with a Ki of approximately 10(-10) M. Compared to its role in the folding reaction, relatively little is known about the mechanism by which the pro region inhibits the...

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PMID: 9092819
DOI: 10.1021/bi962341o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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