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Article

Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide.

Archives of biochemistry and biophysics - 1 Sept 2003

Majerle Andreja, Jerala Roman

Abstract excerpt

The proregion fits tightly into the active site in the tertiary structure of procathepsin L and prevents its activity. We show that complexes between enzyme precursor and its endogenous protein inhibitors-the cystatins-can be formed without prior proteolytic removal of the propeptide. Complexes between cystatins and procathepsin L are formed at acidic pH and their formation is facilitated by acidic...

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Source

Identifiers

PMID: 12921779
DOI: 10.1016/s0003-9861(03)00319-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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