Article
Identification of furin pro-region determinants involved in folding and activation.
The Biochemical journal - 1 May 2004
Bissonnette Lyne, Charest Gabriel, Longpré Jean-Michel, Lavigne Pierre, Leduc Richard
Abstract excerpt
The pro-region of the subtilisin-like convertase furin acts early in the biosynthetic pathway as an intramolecular chaperone to enable proper folding of the zymogen, and later on as an inhibitor to constrain the activity of the enzyme until it reaches the trans -Golgi network. To identify residues that are important for pro-region function, we initially identified amino acids that are conserved among the...
Topics
- Amino Acid Sequence
- Catalytic Domain
- Cell Line
- Enzyme Activation
- Enzyme Precursors
- Furin
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Folding
- Protein Precursors
- Sequence Alignment
- Structural Homology, Protein
- von Willebrand Factor