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Article

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

Biochimie - 1 Mar 2016

Robertson Amy L, Headey Stephen J, Ng Natasha M, Wijeyewickrema Lakshmi C, Scanlon Martin J, Pike Robert N, Bottomley Stephen P

Abstract excerpt

Proteolysis has a critical role in transmitting information within a biological system and therefore an important element of biology is to determine the subset of proteins amenable to proteolysis. Until recently, it has been thought that proteases cleave native protein substrates only within solvent exposed loops, but recent evidence indicates that cleavage sites located within α-helices can also be cleaved by...

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Identifiers

PMID: 26403495
DOI: 10.1016/j.biochi.2015.09.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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