Article
Location of the protease-inhibitory region of secretory leukocyte protease inhibitor.
The Journal of biological chemistry - 15 May 1990
Eisenberg S P, Hale K K, Heimdal P, Thompson R C
Abstract excerpt
Secretory leukocyte protease inhibitor (SLPI) is a two-domain protein that inhibits a wide range of proteases including chymotrypsin, leukocyte elastase, and trypsin. Based on its homology to other protease inhibitors and on x-ray crystallography of an SLPI-chymotrypsin complex it has been proposed that the elastase and chymotrypsin-inhibitory site is in the COOH-terminal domain and that the trypsin-inhibitory...
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