Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.

doi:10.1038/nsb0896-676

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Article

Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.

Nature structural biology - 1 Aug 1996

Elliott P R, Lomas D A, Carrell R W, Abrahams J P

Abstract excerpt

The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the loop in a stable canonical conformation matchin...

Topics

Crystallography, X-Ray
Heparin
Humans
Liver Cirrhosis
Models, Molecular
Mutation
Polymers
Protein Conformation
Structure-Activity Relationship
alpha 1-Antitrypsin

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