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Article

Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme.

The Journal of biological chemistry - 17 Mar 2006

Rabah Nadia, Gauthier Dany, Wilkes Brian C, Gauthier Daniel J, Lazure Claude

Abstract excerpt

The proprotein convertase PC1/3 is synthesized as a large precursor that undergoes proteolytic processing of the signal peptide, the propeptide and ultimately the COOH-terminal tail, to generate the mature form. The propeptide is essential for protease folding, and, although cleaved by an autocatalytic process, it remains associated with the mature form acting as an auto-inhibitor of PC1/3. To further assess the...

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PMID: 16407210
DOI: 10.1074/jbc.M510607200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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