Article
Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.
Endocrinology - 1 Jun 2005
Lee Gene, Makhanova Natalia, Caron Kathleen, Lopez Maria L Sequeira, Gomez R Ariel, Smithies Oliver, Kim Hyung-Suk
Abstract excerpt
To study the effects of decreased amounts or absence of aldosterone on development and endocrine function, we have disrupted the mouse gene, Cyp11b2, coding for aldosterone synthase (AS) by replacing its first two exons with sequences coding for enhanced green fluorescent protein. The null pups fail to thrive postnatally, and about 30% die between d 7 and 28. Aldosterone in plasma and AS mRNA in adrenal glands...
Topics
- Adrenal Cortex
- Aldosterone
- Animals
- Body Weight
- Chlorides
- Corticosterone
- Cytochrome P-450 CYP11B2
- Gene Expression
- Homeostasis
- Hypotension
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Organ Size
- Phenotype
- Potassium
- Renin