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Article

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2.

Molecular & general genetics : MGG - 20 Mar 1995

Georgakopoulos T, Gounalaki N, Thireos G

Abstract excerpt

The GCN5 and ADA2 proteins are required for the activation function of a number of transcriptional activators in the yeast Saccharomyces cerevisiae. By using appropriate LexA fusion proteins we demonstrated that both proteins are required for part of the function of the GCN4, GAL4 and the VP16 tr...

Topics

Cloning, Molecular
DNA-Binding Proteins
Fungal Proteins
Histone Acetyltransferases
Mutation
Plasmids
Protein Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Trans-Activators
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7898440
DOI: 10.1007/BF00290718

Genes

ADA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7898440-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2.PMID 7898440Read ↗

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Semantic proximity Read ↗

The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5.Semantic proximity Read ↗

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.Semantic proximity Read ↗

The DNA target sequence influences the dependence of the yeast transcriptional activator Gcn4 on co-factors.Semantic proximity Read ↗

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.Semantic proximity Read ↗

ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription.Semantic proximity Read ↗

The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.Semantic proximity Read ↗

The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors.Semantic proximity Read ↗

Structure/functional properties of the yeast dual regulator protein NGG1 that are required for glucose repression.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.Semantic proximity Read ↗

GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo.Semantic proximity Read ↗

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