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Article

GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo.

Biochemical and biophysical research communications - 6 Jan 1998

Filetici P, Aranda C, Gonzàlez A, Ballario P

Abstract excerpt

Gcn5p, the nuclear histone acetyltransferase (HAT A), is a component of the multiprotein adaptor complex, ADA. Its role as a transcriptional coactivator is required for full induction of most of the genes regulated by GCN4. In this study we present experimental evidence demonstrating that, during gene activation, the nuclease sensitive region of HIS3 promoter, harbouring the poly (dA:dT) and the GCN4 binding...

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Source

Identifiers

PMID: 9439614
DOI: 10.1006/bbrc.1997.7918

Genes

ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GCN5, a yeast transcriptional coactivator, induces chromatin reconfiguration of HIS3 promoter in vivo.PMID 9439614Read ↗

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.Semantic proximity Read ↗

The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5.Semantic proximity Read ↗

The DNA target sequence influences the dependence of the yeast transcriptional activator Gcn4 on co-factors.Semantic proximity Read ↗

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.Semantic proximity Read ↗

Correlation between chromatin association and transcriptional regulation for the Act3p/Arp4 nuclear actin-related protein of Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2.Semantic proximity Read ↗

Global regulation by the yeast Spt10 protein is mediated through chromatin structure and the histone upstream activating sequence elements.Semantic proximity Read ↗

Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling.Semantic proximity Read ↗

Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast.Semantic proximity Read ↗

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Semantic proximity Read ↗

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