Article
Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1992
Tzamarias D, Pu W T, Struhl K
Abstract excerpt
The bZIP class of eukaryotic transcriptional regulators utilize a distinct structural motif that consists of a leucine zipper that mediates dimerization and an adjacent basic region that directly contacts DNA. Although models of the protein-DNA complex have been proposed, the basis of DNA-binding specificity is essentially unknown. By genetically selecting for derivatives of yeast GCN4 that activate transcription...
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