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Article

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

Molecular and cellular biology - 1 Jun 1997

Horiuchi J, Silverman N, Piña B, Marcus G A, Guarente L

Abstract excerpt

The ADA genes encode factors which are proposed to function as transcriptional coactivators. Here we describe the cloning, sequencing, and initial characterization of a novel ADA gene, ADA1. Similar to the previously isolated ada mutants, ada1 mutants display decreases in transcription from various reporters. Furthermore, ADA1 interacts with the other ADAs in the ADA/GCN5 complex as demonstrated by partial...

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Source

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Identifiers

PMID: 9154821
DOI: 10.1128/MCB.17.6.3220
PMCID: PMC232175

Genes

ADA
ADA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.PMID 9154821Read ↗

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Semantic proximity Read ↗

The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses.Semantic proximity Read ↗

Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression.Semantic proximity Read ↗

The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5.Semantic proximity Read ↗

Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.Semantic proximity Read ↗

The Transcriptional Adaptor Protein ADA3a Modulates Flowering of Arabidopsis thaliana.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2.Semantic proximity Read ↗

ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.Semantic proximity Read ↗

Transcriptional activation of yeast nucleotide biosynthetic gene ADE4 by GCN4.Semantic proximity Read ↗

Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling.Semantic proximity Read ↗

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