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Article

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

The EMBO journal - 17 Oct 1994

Marcus G A, Silverman N, Berger S L, Horiuchi J, Guarente L

Abstract excerpt

A selection for yeast mutants resistant to GAL4-VP16-induced toxicity previously identified two genes, ADA2 and ADA3, which may function as adaptors for some transcriptional activation domains and thereby facilitate activation. Here we identify two new genes by the same selection, one of which is identical to GCN5. We show that gcn5 mutants share properties with ada mutants, including slow growth, temperature...

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Source

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Identifiers

PMID: 7957049
DOI: 10.1002/j.1460-2075.1994.tb06806.x
PMCID: PMC395419

Genes

ADA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.PMID 7957049Read ↗

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2.Semantic proximity Read ↗

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.Semantic proximity Read ↗

ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription.Semantic proximity Read ↗

ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.Semantic proximity Read ↗

Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression.Semantic proximity Read ↗

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.Semantic proximity Read ↗

The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5.Semantic proximity Read ↗

The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

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