Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

The EMBO journal - 1 Nov 1992

Georgakopoulos T, Thireos G

Abstract excerpt

When yeast cells are grown under conditions of amino acid limitation, transcription of amino acid biosynthetic genes is increased through the action of the GCN4 transcriptional regulator. gcn5 mutant strains exhibit poor growth under such conditions. We have established that GCN4 requires the function of GCN5 in order to promote normal levels of transcriptional activation. In addition, we have shown that GCN5 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Sequence Data

Share to Phenotype

Share to Restriction Mapping

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 1396595
DOI: 10.1002/j.1460-2075.1992.tb05507.x
PMCID: PMC556924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.PMID 1396595Read ↗

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.Semantic proximity Read ↗

Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Transcriptional activation of yeast nucleotide biosynthetic gene ADE4 by GCN4.Semantic proximity Read ↗

The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5.Semantic proximity Read ↗

Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5' Promoters in Yeast.Semantic proximity Read ↗

Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling.Semantic proximity Read ↗

Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases.Semantic proximity Read ↗

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Semantic proximity Read ↗

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Semantic proximity Read ↗

The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor.Semantic proximity Read ↗

The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.