Article
Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.
Molecular and cellular biology - 1 Oct 1990
Sellers J W, Vincent A C, Struhl K
Abstract excerpt
The yeast GCN4 transcriptional activator protein binds as a dimer to a dyad-symmetric sequence, indicative of a protein-DNA complex in which two protein monomers interact with adjacent half-sites. However, the optimal GCN4 recognition site, ATGA(C/G)TCAT, is inherently asymmetric because it conta...
Topics
- Base Sequence
- DNA-Binding Proteins
- Fungal Proteins
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Protein Kinases
- RNA, Messenger
- Regulatory Sequences, Nucleic Acid
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Structure-Activity Relationship
- Transcription Factors