Article
The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5.
The Journal of biological chemistry - 18 Sept 1998
Syntichaki P, Thireos G
Abstract excerpt
The Gcn5 histone acetyltransferase (HAT) is part of a large multimeric complex that is required for transcriptional activation in yeast. This complex can acetylate in vitro and in a Gcn5-dependent manner both nucleosomal and free core histones. For this reason it is believed that part of the function of the Gcn5.Ada complex is chromatin remodeling effected by histone acetylation. The roles of the other subunits...
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