Article
The master control gene for morphogenesis and evolution of the eye.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 1996
Gehring W J
Abstract excerpt
The human Aniridia, the murine Small eye, and the eyeless mutations of Drosophila affect homologous (Pax-6) genes that contain both a paired- and a homeobox. By ectopic expression of these genes, functional eyes can be induced on the legs, wings, and antennae of the fly, indicating that eyeless (...
Topics
- Animals
- Biological Evolution
- DNA-Binding Proteins
- Drosophila
- Eye
- Eye Proteins
- Genes
- Genes, Homeobox
- Genes, Insect
- Homeodomain Proteins
- Humans
- Mice
- Morphogenesis
- Mutation
- PAX6 Transcription Factor
- Paired Box Transcription Factors
- Repressor Proteins