Article
The master control gene for morphogenesis and evolution of the eye.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 1996
Gehring W J
Abstract excerpt
The human Aniridia, the murine Small eye, and the eyeless mutations of Drosophila affect homologous (Pax-6) genes that contain both a paired- and a homeobox. By ectopic expression of these genes, functional eyes can be induced on the legs, wings, and antennae of the fly, indicating that eyeless (Pax-6) is the master control gene for eye morphogenesis. The finding of Pax-6 from flatworms to humans suggests that...
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