Article
Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila.
Developmental biology - 15 Oct 2009
Clements Jason, Hens Korneel, Merugu Srinivas, Dichtl Beatriz, de Couet H Gert, Callaerts Patrick
Abstract excerpt
Pax6 genes encode evolutionarily highly conserved transcription factors that are required for eye and brain development. Despite the characterization of mutations in Pax6 homologs in a range of organisms, and despite functional studies, it remains unclear what the relative importance is of the various parts of the Pax6 protein. To address this, we have studied the Drosophila Pax6 homolog eyeless. Specifically, we...
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