Article
Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.
Science (New York, N.Y.) - 24 Mar 1995
Halder G, Callaerts P, Gehring W J
Abstract excerpt
The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans. These genes share extensive sequence identity, the position of three intron splice sites is conserved, and these genes are expressed similarly in the developing nervous system and in the eye during morphogenesis....
Topics
- Animals
- Drosophila
- Eye
- Gene Expression Regulation
- Genes, Homeobox
- Genes, Insect
- Genes, Reporter
- Microscopy, Electron, Scanning
- Mutation
- Photoreceptor Cells, Invertebrate
- beta-Galactosidase