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Article

twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development.

Molecular cell - 1 Mar 1999

Czerny T, Halder G, Kloter U, Souabni A, Gehring W J, Busslinger M

Abstract excerpt

The Drosophila Pax-6 gene eyeless (ey) plays a key role in eye development. Here we show tht Drosophila contains a second Pax-6 gene, twin of eyeless (toy), due to a duplication during insect evolution. Toy is more similar to vertebrate Pax-6 proteins than Ey with regard to overall sequence conservation, DNA-binding function, and early expression in the embryo, toy and ey share a similar expression pattern in the...

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PMID: 10198632
DOI: 10.1016/s1097-2765(00)80457-8

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