A somatic mutation of the p21(Waf1/Cip1) gene in a human adrenocortical adenoma.

Article

A somatic mutation of the p21(Waf1/Cip1) gene in a human adrenocortical adenoma.

Anticancer research - 1 Jan 2000

Iida S, Fujii H, Moriwaki K

Abstract excerpt

The p21(Waf1/Cip1) protein, an inhibitory protein of cellular growth and DNA replication, is induced by the p53 tumour suppressor protein. Any mutations or deletions inactivating the protein may result in unregulated cellular growth. In one aldosterone secreting adrenocortical adenoma, we found a...

Topics

Adenoma
Adrenal Cortex Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Humans
Mutation
Neoplasm Proteins
Polymerase Chain Reaction
Sequence Deletion

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