Article
No point mutation but a codon 31ser-->arg polymorphism of the WAF-1/CIP-1/p21 tumor suppressor gene in nasopharyngeal carcinoma (NPC): the polymorphism distinguishes Caucasians from Chinese.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2000
Sun Y, Hildesheim A, Li H, Li Y, Chen J Y, Cheng Y J, Hayes R B, Rothman N, Bi W F, Cao Y
Abstract excerpt
Mutational inactivation of the p53 tumor suppressor gene is an infrequent event in human nasopharyngeal carcinoma (NPC), a malignancy showing a high incidence in southern China and southeast Asia. To examine the possible involvement of an activated p53 pathway in nasopharynx carcinogenesis, we have screened primary NPC biopsies for possible point mutations in WAF-1/CIP-1/p21, an effector gene transcriptionally...
Topics
- Animals
- Asian People
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Codon
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Mutational Analysis