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Article

Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant melanomas.

Melanoma research - 1 Aug 1995

Vidal M J, Loganzo F, de Oliveira A R, Hayward N K, Albino A P

Abstract excerpt

The WAF1 gene, located on chromosome 6p, encodes a M(r) 21,000 protein (p21) that can arrest cell growth by associating with and inhibiting cyclin-dependent kinase complexes that are necessary for cells to exit Gr. Transcriptional activation of WAF1 can be accomplished by increasing levels of p53 protein induced by various cellular stresses, including DNA damage. Metastatic melanomas are paradoxical in that most...

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Source

Identifiers

PMID: 7496159
DOI: 10.1097/00008390-199508000-00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant melanomas.PMID 7496159Read ↗

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Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.Semantic proximity Read ↗

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma.Semantic proximity Read ↗

p21WAF1 mutations and human malignancies.Semantic proximity Read ↗

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