Article
Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant melanomas.
Melanoma research - 1 Aug 1995
Vidal M J, Loganzo F, de Oliveira A R, Hayward N K, Albino A P
Abstract excerpt
The WAF1 gene, located on chromosome 6p, encodes a M(r) 21,000 protein (p21) that can arrest cell growth by associating with and inhibiting cyclin-dependent kinase complexes that are necessary for cells to exit Gr. Transcriptional activation of WAF1 can be accomplished by increasing levels of p53...
Topics
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA, Neoplasm
- Gene Expression
- Genes, Tumor Suppressor
- Humans
- Lymphocytes
- Melanocytes
- Melanoma
- Mutation
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger
- Reference Values
- Tumor Suppressor Protein p53