Article
Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women.
International journal of molecular medicine - 1 Mar 2001
Harima Y, Sawada S, Nagata K, Sougawa M, Ostapenko V, Ohnishi T
Abstract excerpt
The WAF1 gene, located on chromosome 6p21.2, has been cloned and identified as a p53 mediator and an inhibitor of G1 cyclin-dependent kinases (CDKs). The present study was performed to investigate the possible role of the WAF1 gene in the pathogenesis of human cervical carcinoma. Matched venous blood and cancer tissues from 66 patients with cervical cancer were screened for WAF1 mutation by reverse...
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