Article
Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.
Human molecular genetics - 1 Jun 1995
Mousses S, Ozçelik H, Lee P D, Malkin D, Bull S B, Andrulis I L
Abstract excerpt
Several groups have recently isolated and characterized an inhibitor of cyclin-dependent kinases, p21CIP1/WAF1 which is transcriptionally induced by wild-type but not mutant p53. It is likely that p21CIP1/WAF1 mediates the growth suppression effects of p53 by arresting the cell cycle at the G1/S...
Topics
- Breast Neoplasms
- Chromosomes, Human, Pair 6
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- Humans
- Molecular Sequence Data
- Mutation
- Neuroblastoma
- Polymerase Chain Reaction
- Rhabdomyosarcoma
- Sarcoma