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Article

T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

The Journal of experimental medicine - 1 Sept 1996

Zheng B, Han S, Kelsoe G

Abstract excerpt

After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen-specific...

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Identifiers

PMID: 9064325
DOI: 10.1084/jem.184.3.1083
PMCID: PMC2192770

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Source receipt: pubmed, retrieved 7 Sept 2026.

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