Article
CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone.
European journal of immunology - 1 Feb 2000
Voigt I, Camacho S A, de Boer B A, Lipp M, Förster R, Berek C
Abstract excerpt
The chemokine receptor CXCR5 is thought to be essential for the migration of B cells into the network of follicular dendritic cells in the spleen. However, as shown here, B cells and follicular dendritic cells do co-localize, albeit aberrantly, even in the absence of CXCR5. In mice lacking CXCR5 both cell types are found in a broad ring around the sinuses of the marginal zones. Upon immunization with the T...
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