Article
Maturation and emigration of single-positive thymocytes.
Clinical & developmental immunology - 1 Jan 2013
Xu Xi, Zhang Shusong, Li Pingping, Lu Jin, Xuan Qun, Ge Qing
Abstract excerpt
T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are "fully mature" and waiting to be exported at random or follow a "first-in-first-out" manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated...
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