Article
Retention and tolerance of autoreactive CD4(+) recent thymic emigrants in the liver.
Journal of autoimmunity - 1 Jan 2015
Xu Xi, Zhang Shusong, Jin Rong, Wang Ke, Li Pingping, Lin Liang, Dong Jie, Hao Jie, Zhang Yan, Sun Xiuyuan, Pang Xuewen, Qian Xiaoping, Zhang Jun, Wu Hounan, Zhang Yu, Ge Qing
Abstract excerpt
Mechanisms of peripheral tolerance play a critical role in preventing T cells that escape from negative selection in the thymus from initiating autoimmune reactions. To investigate the site of peripheral tolerance induction, we examined migration and activation of recent thymic emigrants (RTEs) in liver, spleen, lymph node and peripheral blood. We show that a fraction of RTE precursors were retained in the liver...
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