Article
Lymphocytes with a CD4+ CD8- CD3- phenotype are effectors of experimental cutaneous graft-versus-host disease.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1991
Sakamoto H, Michaelson J, Jones W K, Bhan A K, Abhyankar S, Silverstein M, Golan D E, Burakoff S J, Ferrara J L
Abstract excerpt
Graft-versus-host disease (GVHD) is known to cause profound dysregulation of the immune system, although its effector mechanisms are poorly understood. We now describe an effector lymphocyte of unusual phenotype in the skin of mice with GVHD. This cell is of donor origin and expresses several T-cell surface proteins including Thy-1, CD2, and CD4 but does not express CD8, CD3, NK1.1, or macrophage antigens....
Topics
- Animals
- Antigens, Differentiation, T-Lymphocyte
- Bone Marrow Transplantation
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Fluorescein-5-isothiocyanate
- Fluorescent Antibody Technique
- Graft vs Host Disease