Article
CD21high IgMhigh splenic B cells enriched in the marginal zone: distinct phenotypes and functions.
Current topics in microbiology and immunology - 1 Jan 1999
Martin F, Kearney J F
Abstract excerpt
Collectively, these findings suggest that MZ B cells have unique signaling and subsequent differentiative capabilities that permit them to react much more vigorously than the majority of splenic B cells (FO) in the earliest stages of an in vivo immune response. This is particularly evident with limiting T cell help, low concentration of thymus-independent mitogens or low amounts of particulate blood-borne antigen...
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