Article
Identification of the rat adapter Grb14 as an inhibitor of insulin actions.
The Journal of biological chemistry - 2 Oct 1998
Kasus-Jacobi A, Perdereau D, Auzan C, Clauser E, Van Obberghen E, Mauvais-Jarvis F, Girard J, Burnol A F
Abstract excerpt
We cloned by interaction with the beta-subunit of the insulin receptor the rat variant of the human adapter Grb14 (rGrb14). rGrb14 is specifically expressed in rat insulin-sensitive tissues and in the brain. The binding of rGrb14 to insulin receptors is insulin-dependent in vivo in Chinese hamste...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- CHO Cells
- Cloning, Molecular
- Cricetinae
- Insulin
- Liver
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Phosphotyrosine
- Proteins
- RNA, Messenger
- Rats
- Receptor Protein-Tyrosine Kinases