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Article

The Insulin Receptor Isoform Exon 11- (IR-A) in Cancer and Other Diseases: A Review

1 Nov 2003

Abstract excerpt

The insulin receptor plays a vital role in mediating the actions of insulin. These include metabolic and mitogenic effects. This review will focus on the role of the insulin receptor isoforms in normal development and the pathogenesis of certain cancers and type 2 diabetes. There are two insulin receptor isoforms arising from the alternative splicing of exon 11 resulting in either the exon 11+ (IR-B) isoform...

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Identifiers

PMID: 14710358
DOI: 10.1055/s-2004-814157

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