Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.

The Journal of biological chemistry - 31 Jan 1997

Frantz J D, Giorgetti-Peraldi S, Ottinger E A, Shoelson S E

Abstract excerpt

cDNA clones encoding human (h) Grb7 and a previously unknown protein with high homology to hGrb-IR and mGrb10 (where m indicates mouse) were found by screening expressed sequence tag data bases. hGrb7 mRNA expression is greatest in pancreas and restricted to a few other tissues. The second protein termed hGrb-IRbeta/Grb10 contains an intact PH domain and lacks the 80-residue mGrb10 insertion. Expression is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Binding Sites

Share to Cloning, Molecular

Share to DNA Primers

Share to Genetic Variation

Share to Molecular Sequence Data

Source

Identifiers

PMID: 9006901
DOI: 10.1074/jbc.272.5.2659

Genes

GRB10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.PMID 9006901Read ↗

Grb10 and Grb14: enigmatic regulators of insulin action--and more?Semantic proximity Read ↗

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.Semantic proximity Read ↗

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.Semantic proximity Read ↗

Identification of the rat adapter Grb14 as an inhibitor of insulin actions.Semantic proximity Read ↗

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life.Semantic proximity Read ↗

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.Semantic proximity Read ↗

A central role for GRB10 in regulation of islet function in man.Semantic proximity Read ↗

Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunctionSemantic proximity Read ↗

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and DiseaseSemantic proximity Read ↗

The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.Semantic proximity Read ↗

Identification of the <i>Meg1</i> / <i>Grb10</i> imprinted gene on mouse proximal chromosome 11, a candidate for the Silver–Russell syndrome geneSemantic proximity Read ↗

Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) That Arise from an Exon-skipping Mechanism of Alternative Splicing of the Transcript from the iPLA2 Gene on Chromosome 22q13.1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.