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Article

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.

Molecular and cellular biology - 1 May 2003

Vecchione Andrea, Marchese Adriano, Henry Pauline, Rotin Daniela, Morrione Andrea

Abstract excerpt

The adapter protein Grb10 belongs to a superfamily of related proteins, including Grb7, -10, and -14 and Caenorhabditis elegans Mig10. Grb10 is an interacting partner of the insulin-like growth factor I receptor (IGF-IR) and the insulin receptor (IR). Previous work showed an inhibitory effect of mouse Grb10 (mGrb10alpha) on IGF-I-mediated mitogenesis (A. Morrione et al., J. Biol. Chem. 272:26382-26387, 1997)....

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Identifiers

PMID: 12697834
DOI: 10.1128/MCB.23.9.3363-3372.2003
PMCID: PMC153198

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Source receipt: pubmed, retrieved 7 Sept 2026.

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