Article
Allelic loss detected on chromosomes 8, 10, and 17 by fluorescence in situ hybridization using single-copy P1 probes on isolated nuclei from paraffin-embedded prostate tumors.
The American journal of pathology - 1 Mar 1997
Deubler D A, Williams B J, Zhu X L, Steele M R, Rohr L R, Jensen J C, Stephenson R A, Changus J E, Miller G J, Becich M J, Brothman A R
Abstract excerpt
We have implemented a reliable new technique for preparing isolated prostate cancer nuclei from paraffin-embedded tissue sections followed by analysis with single-copy fluorescence in situ hybridization (FISH). Our initial validation is described by comparison of our data with fresh prostate tumor tissue and loss of heterozygosity (LOH) studies. We also describe evaluation of 36 previously unstudied prostate...
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