Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990

Carter B S, Ewing C M, Ward W S, Treiger B F, Aalders T W, Schalken J A, Epstein J I, Isaacs W B

Abstract excerpt

Recent advances in understanding the molecular genetics of common adult tumors have indicated that multiple genetic alterations including the activation of oncogenes and the inactivation of tumor suppressor genes are important in the pathogenesis of these tumors. Loss of heterozygosity is a hallmark of tumor suppressor gene inactivation and has been used to identify chromosomal regions that contain these genes....

Topics

Alleles
Blotting, Southern
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 16
DNA Probes
Genes, Tumor Suppressor
Humans
Male
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 1978938
DOI: 10.1073/pnas.87.22.8751
PMCID: PMC55037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1978938-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic loss of chromosomes 16q and 10q in human prostate cancer.PMID 1978938Read ↗

Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer.Semantic proximity Read ↗

Allelic loss on chromosome 10 in prostate adenocarcinoma.Semantic proximity Read ↗

Three independently deleted regions at chromosome arm 16q in human prostate cancer: allelic loss at 16q24.1-q24.2 is associated with aggressive behaviour of the disease, recurrent growth, poor differentiation of the tumour and poor prognosis for the patient.Semantic proximity Read ↗

Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer.Semantic proximity Read ↗

Allelic imbalance mapping of chromosome 16 shows two regions of common deletion in prostate adenocarcinoma.Semantic proximity Read ↗

Distinct regions of allelic loss on 13q in prostate cancer.Semantic proximity Read ↗

Allelic loss on chromosome 13q in human prostate carcinoma.Semantic proximity Read ↗

Loss of heterozygosity at chromosome 16q in prostate adenocarcinoma: identification of three independent regions.Semantic proximity Read ↗

Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer.Semantic proximity Read ↗

Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.Semantic proximity Read ↗

Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer.Semantic proximity Read ↗

Review of allelic loss and gain in prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.