Article
Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.
Cancer research - 15 May 1996
Vocke C D, Pozzatti R O, Bostwick D G, Florence C D, Jennings S B, Strup S E, Duray P H, Liotta L A, Emmert-Buck M R, Linehan W M
Abstract excerpt
To investigate the possible involvement of a tumor suppressor gene(s) on chromosome 8 in prostatic neoplasms, we performed a comprehensive loss of heterozygosity (LOH) study on 99 tumors from 97 prostate cancer patients. One of the carcinomas was a lymph node metastasis; the other 98 were primary...
Topics
- Aged
- Alleles
- Chromosomes, Human, Pair 8
- DNA, Neoplasm
- Frozen Sections
- Gene Deletion
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Lymphatic Metastasis
- Male
- Microtomy
- Middle Aged
- Neoplasm Staging
- Ploidies
- Polymerase Chain Reaction
- Prostatic Neoplasms