Article
Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.
Cancer research - 15 May 1996
Vocke C D, Pozzatti R O, Bostwick D G, Florence C D, Jennings S B, Strup S E, Duray P H, Liotta L A, Emmert-Buck M R, Linehan W M
Abstract excerpt
To investigate the possible involvement of a tumor suppressor gene(s) on chromosome 8 in prostatic neoplasms, we performed a comprehensive loss of heterozygosity (LOH) study on 99 tumors from 97 prostate cancer patients. One of the carcinomas was a lymph node metastasis; the other 98 were primary carcinomas. Pure populations of carcinoma cells and normal epithelia were procured by tissue microdissection. Two...
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