Article
Loss of chromosome arm 8p loci in prostate cancer: mapping by quantitative allelic imbalance.
Genes, chromosomes & cancer - 1 Jul 1994
MacGrogan D, Levy A, Bostwick D, Wagner M, Wells D, Bookstein R
Abstract excerpt
A previous study of 18 primary or metastatic prostate cancers showed loss of genetic markers on chromosome 8; 10, or 16 in more than 50% of cases [Bergerheim USR et al. (1991) Genes Chromosom Cancer 3:215-220]. The small size and infiltrative nature of primary prostatic tumors have hindered efforts to assess allelic losses by traditional restriction fragment length polymorphism (RFLP)/Southern blotting methods....
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- DNA Primers
- DNA, Neoplasm
- DNA, Satellite
- Humans
- Male