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Article

Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations.

Journal of theoretical biology - 21 Jan 1997

Nowak M A, Bonhoeffer S, Shaw G M, May R M

Abstract excerpt

Anti-viral drug treatment of infections with the human immunodeficiency virus type I (HIV-1) usually leads to a rapid decline in the abundance of plasma virus. The effect of single drug therapy, however, is often only short-lived as the virus readily develops drug-resistant mutants. In this paper we provide analytic approximations for the rate of emergence of resistant virus. We study the decline of wildtype...

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Source

Identifiers

PMID: 9059598
DOI: 10.1006/jtbi.1996.0307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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