Article
A stochastic model for primary HIV infection: optimal timing of therapy.
AIDS (London, England) - 25 Feb 1999
Ribeiro R M, Bonhoeffer S
Abstract excerpt
OBJECTIVE: To investigate the optimal time point for the initiation of therapy in HIV infection from the perspective of drug resistance. BACKGROUND: The enormous genetic diversity of HIV within an infected individual represents one of the greatest challenges for effective therapy, because the viral population may harbour drug-resistant mutants that rapidly outgrow the wild-type virus once the patient starts...
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