Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations.

Theoretical biology & medical modelling - 14 Nov 2008

Shiri Tinevimbo, Welte Alex

Abstract excerpt

BACKGROUND: Highly selective antiretroviral (ARV) regimens such as single dose nevirapine (NVP) used for prevention of mother to child transmission (PMTCT) in resource-limited settings produce transient increases in otherwise marginal subpopulations of cells infected by mutant genomes. The longer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Infectious Disease Transmission, Vertical
Share to Models, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nevirapine

Share to Pregnancy Complications, Infectious

Share to Stochastic Processes

Share to Virology

Source

Open in PubMed Open full text

Identifiers

PMID: 19014593
DOI: 10.1186/1742-4682-5-25
PMCID: PMC2605440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19014593-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations.PMID 19014593Read ↗

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.Semantic proximity Read ↗

Residual Viremia in Treated HIV+ IndividualsSemantic proximity Read ↗

Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapySemantic proximity Read ↗

Modeling sequence evolution in acute HIV-1 infection.Semantic proximity Read ↗

Differential persistence of transmitted HIV-1 drug resistance mutation classes.Semantic proximity Read ↗

Emergence of recombinant forms of HIV: dynamics and scaling.Semantic proximity Read ↗

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds.Semantic proximity Read ↗

Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles.Semantic proximity Read ↗

A stochastic model for primary HIV infection: optimal timing of therapy.Semantic proximity Read ↗

Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection.Semantic proximity Read ↗

Mutation takes no vacation: can structured treatment interruptions increase the risk of drug-resistant HIV-1?Semantic proximity Read ↗

A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIVSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.