Article
Viral dynamics in human immunodeficiency virus type 1 infection.
Nature - 12 Jan 1995
Wei X, Ghosh S K, Taylor M E, Johnson V A, Emini E A, Deutsch P, Lifson J D, Bonhoeffer S, Nowak M A, Hahn B H
Abstract excerpt
The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarka...
Topics
- Antiviral Agents
- Base Sequence
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Cell Survival
- DNA, Viral
- Drug Resistance, Microbial
- Genotype
- HIV Infections
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Phenotype
- RNA, Viral