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Article

Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model.

Journal of virology - 1 Jan 1997

Stilianakis N I, Boucher C A, De Jong M D, Van Leeuwen R, Schuurman R, De Boer R J

Abstract excerpt

Treatment of human immunodeficiency virus type 1 (HIV-1) infection during the clinical latency phase with drugs inhibiting reverse transcriptase (RT) reduces the HIV-1 RNA load and increases the CD4+ T-cell count. Typically, however, the virus evolves mutations in the RT gene that circumvent the drugs. We develop a mathematical model for this situation. The model distinguishes quiescent from activated CD4+ T...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8985335
DOI: 10.1128/JVI.71.1.161-168.1997
PMCID: PMC191036

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Source receipt: pubmed, retrieved 7 Sept 2026.

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