Article
Clinical data sets of human immunodeficiency virus type 1 reverse transcriptase-resistant mutants explained by a mathematical model.
Journal of virology - 1 Jan 1997
Stilianakis N I, Boucher C A, De Jong M D, Van Leeuwen R, Schuurman R, De Boer R J
Abstract excerpt
Treatment of human immunodeficiency virus type 1 (HIV-1) infection during the clinical latency phase with drugs inhibiting reverse transcriptase (RT) reduces the HIV-1 RNA load and increases the CD4+ T-cell count. Typically, however, the virus evolves mutations in the RT gene that circumvent the drugs. We develop a mathematical model for this situation. The model distinguishes quiescent from activated CD4+ T...
Topics
- Drug Resistance, Microbial
- Genetic Variation
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lamivudine
- Mathematical Computing
- Models, Biological
- Mutation
- Reverse Transcriptase Inhibitors
- Zidovudine