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Article

Mutation takes no vacation: can structured treatment interruptions increase the risk of drug-resistant HIV-1?

Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2000

Dorman K S, Kaplan A H, Lange K, Sinsheimer J S

Abstract excerpt

We use a mathematical model to study the dynamics of HIV-1 replication during structured treatment interruptions (STIs) in infected patients. The model predicts rapid viral rebound, restoration of a latently infected cell pool, and critically, partially resistant mutant rebound that may be missed because of high levels of wild type virus. Because partially resistant viruses are capable of mutating to full...

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Identifiers

PMID: 11141239
DOI: 10.1097/00042560-200012150-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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