Article
TP53 mutations in canine brain tumors.
Veterinary pathology - 1 Sept 2012
York D, Higgins R J, LeCouteur R A, Wolfe A N, Grahn R, Olby N, Campbell M, Dickinson P J
Abstract excerpt
The p53 tumor suppressor gene (TP53) is the most frequently altered gene in human cancer. Mutation of the gene has been shown to be an important mechanism of p53 pathway inactivation in a variety of human brain tumors, particularly those of astrocytic origin. Genomic DNA from a series of 37 glial and 51 nonglial canine brain tumors was sequenced to determine the frequency of TP53 gene mutations involving exons...
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