Article
Malignant transformation induced by cytokine genes: a comparison of the abilities of germline and mutated interleukin 3 genes to transform hematopoietic cells by transcriptional and posttranscriptional mechanisms.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Apr 1996
Wang X Y, McCubrey J A
Abstract excerpt
The effects of inheritance of germline (gIL3) and rearranged interleukin 3 (rIL3) genes on the factor dependency and tumorigenicity of a hematopoietic cell line were compared. The rIL3 gene arose after intracisternal type A particle transposition into the 3' untranslated region (UTR). The rlL3 ge...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Electroporation
- Genes, Intracisternal A-Particle
- Hematopoietic Stem Cells
- Interleukin-3
- Lymphocytes