Article
Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene.
Blood - 1 May 1995
Hara T, Ichihara M, Takagi M, Miyajima A
Abstract excerpt
Interleukin-3 (IL-3) stimulates colony formation of multiple lineages of hematopoietic cells. Bone marrow cells of A/J mice are nonresponsive to IL-3, and this observation has recently been correlated with aberrant mRNA splicing and impaired expression of the IL-3 receptor alpha subunit (IL-3R al...
Topics
- Alleles
- Animals
- Base Sequence
- Bone Marrow
- Colony-Forming Units Assay
- DNA Mutational Analysis
- Drug Resistance
- Female
- Genes
- Genes, Recessive
- Hematopoietic Stem Cells
- Interleukin-3
- Mice
- Mice, Inbred A
- Mice, Inbred Strains
- Molecular Sequence Data
- Phenotype
- Phylogeny