Sequential mutations in the interleukin-3 (IL3)/granulocyte-macrophage colony-stimulating factor/IL5 receptor beta-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated beta C subunit.

doi:10.1128/MCB.15.5.2402

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Article

Sequential mutations in the interleukin-3 (IL3)/granulocyte-macrophage colony-stimulating factor/IL5 receptor beta-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated beta C subunit.

Molecular and cellular biology - 1 May 1995

Hannemann J, Hara T, Kawai M, Miyajima A, Ostertag W, Stocking C

Abstract excerpt

An amino-terminally truncated beta C receptor (beta C-R) subunit of the interleukin-3 (IL3)/granulocyte-macrophage colony-stimulating factor/IL5 receptor complex mediates factor-independent and tumorigenic growth in two spontaneous mutants of a promyelocytic cell line. The constitutive activation of the JAK2 protein kinase in these mutants confirms that signaling occurs through the truncated receptor protein....

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Cell Division
Cell Line
DNA, Complementary
Exons
Granulocyte-Macrophage Colony-Stimulating Factor
Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-3

Introns

Janus Kinase 2

Leukemia, Experimental

Mice

Molecular Sequence Data

Mutation

Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 7739524
DOI: 10.1128/MCB.15.5.2402
PMCID: PMC230469

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7739524-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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